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Hung, Lin W; Villemagne, Victor L; Cheng, Lesley; Sherratt, Nicki A; Ayton, Scott; White, Anthony R; Crouch, Peter J; Lim, SinChun; Leong, Su Ling; Wilkins, Simon; George, Jessica; Roberts, Blaine R; Pham, Chi L L; Liu, Xiang; Chiu, Francis C K; Shackleford, David M; Powell, Andrew K; Masters, Colin L; Bush, Ashley I; O'Keefe, Graeme; Culvenor, Janetta G; Cappai, Roberto; Cherny, Robert A; Donnelly, Paul S; Hill, Andrew F; Finkelstein, David I; Barnham, Kevin J
The Journal of experimental medicine, 04/2012, Letnik: 209, Številka: 4Journal Article
Parkinson's disease (PD) is a progressive, chronic disease characterized by dyskinesia, rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies, which primarily consist of aggregated α-synuclein protein, and is accompanied by the loss of monoaminergic neurons. Current therapeutic strategies only give symptomatic relief of motor impairment and do not address the underlying neurodegeneration. Hence, we have identified Cu(II)(atsm) as a potential therapeutic for PD. Drug administration to four different animal models of PD resulted in improved motor and cognition function, rescued nigral cell loss, and improved dopamine metabolism. In vitro, this compound is able to inhibit the effects of peroxynitrite-driven toxicity, including the formation of nitrated α-synuclein oligomers. Our results show that Cu(II)(atsm) is effective in reversing parkinsonian defects in animal models and has the potential to be a successful treatment of PD.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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