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de Abreu, Murilo S; Demin, Konstantin A; Kotova, Maria M; Mirzaei, Foad; Shariff, Sanobar; Kantawala, Burhan; Zakharchenko, Ksenia V; Kolesnikova, Tatiana O; Dilbaryan, Karen; Grigoryan, Artem; Yenkoyan, Konstantin B; Kalueff, Allan V
International journal of molecular sciences, 01/2023, Letnik: 24, Številka: 2Journal Article
The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expression and axonal regeneration. Aberrant mTOR signaling causes a diverse group of neurological disorders, termed 'mTORopathies'. Typically arising from mutations within the mTOR signaling pathway, these disorders are characterized by cortical malformations and other neuromorphological abnormalities that usually co-occur with severe, often treatment-resistant, epilepsy. Here, we discuss recent advances and current challenges in developing experimental models of mTOR-dependent epilepsy and other related mTORopathies, including using zebrafish models for studying these disorders, as well as outline future directions of research in this field.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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