Background Esophagogastric junction outflow obstruction (EGJOO) is a newly described diagnostic entity growing in importance due to the use of high resolution manometry (HRM). There is little knowledge regarding its incidence, etiopathogeny, long‐term evolution, and most suitable treatment. Our objective was to increase the awareness of EGJOO to optimize the management of these patients. Methods We conducted a historical (retrospective and prospective) study of patients diagnosed with EGJOO using HRM combined with multichannel intraluminal impedance, comparing their manometric and impedance characteristics with those of a control group. Symptoms, etiology of obstruction, acid exposure, clinical course (and its associated factors), and response to treatment were also evaluated in the EGJOO group. Key Results Forty‐four subjects were included (28 patients and 16 controls). Esophagogastric junction outflow obstruction patients presented incomplete esophageal transit more frequently than controls. Patients with structural obstruction had dysphagia more frequently than patients with functional obstruction, and different manometric, impedance, and pH‐metric patterns. Over one‐third of the EGJOO patients presented a spontaneous resolution of symptoms without EGJOO treatment. In the multivariate analysis, the variables associated with this spontaneous symptomatic resolution included typical symptoms of gastro‐esophageal reflux disease or epigastralgia as the main symptom and resting or basal pressure of the upper esophageal sphincter <50 mmHg. Conclusions & Inferences The majority of EGJOO patients presented intact peristalsis which may compensate for the lack of EGJ relaxation. In the EGJOO patients presenting favorable factors associated with a spontaneous resolution of symptoms, invasive treatments should be considered with special caution. Structural etiologies are more amenable to management, while the remainder may improve without intervention. Esophagogastric junction outflow obstruction is a newly described diagnosis entity, growing in importance due to the use of HRM. We study the manometric and impedance characteristics of a group of EGJOO patients (vs a control group), and their symptoms, etiology of obstruction, acid exposure, clinical course (and its associated factors), and response to treatment. We conclude that the majority of EGJOO patients present intact peristalsis which may compensate for the lack of EGJ relaxation, and that in the EGJOO patients presenting favorable factors associated with a spontaneous resolution of symptoms, invasive treatments should be considered with special caution. Both structural and non‐structural etiologies can cause EGJOO, but structural etiologies are more amenable to management, while the remainder may improve without intervention.