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Shabel, Steven J.; Proulx, Christophe D.; Trias, Anthony; Murphy, Ryan T.; Malinow, Roberto
Neuron, 05/2012, Letnik: 74, Številka: 3Journal Article
The lateral habenula (LHb) has recently been identified as a key regulator of the reward system by driving inhibition onto dopaminergic neurons. However, the nature and potential modulation of the major input to the LHb originating from the basal ganglia are poorly understood. Although the output of the basal ganglia is thought to be primarily inhibitory, here we show that transmission from the basal ganglia to the LHb is excitatory, glutamatergic, and suppressed by serotonin. Behaviorally, activation of this pathway is aversive, consistent with its role as an “antireward” signal. Our demonstration of an excitatory projection from the basal ganglia to the LHb explains how LHb-projecting basal ganglia neurons can have similar encoding properties as LHb neurons themselves. Our results also provide a link between antireward excitatory synapses and serotonin, a neuromodulator implicated in depression. ► Input to the lateral habenula from the basal ganglia is excitatory ► Excitatory input to the lateral habenula from the basal ganglia is glutamatergic ► Input to the lateral habenula from the basal ganglia is aversive ► Serotonin suppresses excitatory input to the LHb from the basal ganglia Shabel et al. characterize a major input to the lateral habenula, a brain region involved in reward, and show that this input is aversive and suppressed by serotonin, providing a link between aversive signaling and a neuromodulator involved in depression.
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