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Park, Eun-Sil; Shimojima, Masayuki; Nagata, Noriyo; Ami, Yasushi; Yoshikawa, Tomoki; Iwata-Yoshikawa, Naoko; Fukushi, Shuetsu; Watanabe, Shumpei; Kurosu, Takeshi; Kataoka, Michiyo; Okutani, Akiko; Kimura, Masanobu; Imaoka, Koichi; Hanaki, Kenichi; Suzuki, Tadaki; Hasegawa, Hideki; Saijo, Masayuki; Maeda, Ken; Morikawa, Shigeru
Scientific reports, 08/2019, Letnik: 9, Številka: 1Journal Article
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by the SFTS phlebovirus (SFTSV). SFTS patients were first reported in China, followed by Japan and South Korea. In 2017, cats were diagnosed with SFTS for the first time, suggesting that these animals are susceptible to SFTSV. To confirm whether or not cats were indeed susceptible to SFTSV, animal subjects were experimentally infected with SFTSV. Four of the six cats infected with the SPL010 strain of SFTSV died, all showing similar or more severe symptoms than human SFTS patients, such as a fever, leukocytopenia, thrombocytopenia, weight loss, anorexia, jaundice and depression. High levels of SFTSV RNA loads were detected in the serum, eye swab, saliva, rectal swab and urine, indicating a risk of direct human infection from SFTS-infected animals. Histopathologically, acute necrotizing lymphadenitis and hemophagocytosis were prominent in the lymph nodes and spleen. Severe hemorrhaging was observed throughout the gastrointestinal tract. B cell lineage cells with MUM-1 and CD20, but not Pax-5 in the lesions were predominantly infected with SFTSV. The present study demonstrated that cats were highly susceptible to SFTSV. The risk of direct infection from SFTS-infected cats to humans should therefore be considered.
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in: SICRIS
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