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  • Evidence and antibiotic res...
    Attili, Anna-Rita; Nocera, Francesca Paola; Sisto, Martina; Linardi, Martina; Gigli, Francesca; Ngwa, Victor Ngu; Fiorito, Filomena; Cerracchio, Claudia; Meligrana, Marina C.T.; Bonacucina, Eleonora; Cuteri, Vincenzo; De Martino, Luisa

    Comparative immunology, microbiology and infectious diseases, June 2024, 2024-Jun, 2024-06-00, 20240601, Letnik: 109
    Journal Article

    To evaluate the frequency of Acinetobacter spp., belonging to both Acinetobacter calcoaceticus-baumannii (ACB) and non-ACB complex, and their antibiotic resistance profiles in veterinary medicine, a three-year (2020–2022) retrospective study was carried out on sick companion animals. Epidemiological data from different clinical canine, feline, and equine samples, were acquired. For each strain, MALDI-TOF MS identification and susceptibility to a panel of 11 antibiotics, by Kirby-Bauer and E-test methods, were performed. Out of 628 bacteriological examinations, 2.5% resulted positive for strains belonging to Acinetobacter genus. Frequencies of 2.3%, 1.9%, and 3% were obtained from both in-visiting and hospitalized dogs, cats, and horses, respectively. Members of ACB-complex accounted for 50% of isolates. Since all strains resulted susceptible to aminoglycosides and polymyxins, no pandrug-resistant (PDR) species were recorded. While 12.5% A. baumannii resulted extensively-drug resistant (XDR), a higher percentage of multidrug-resistant strains was recorded among non-ACB strains (35.5%) than ACB strains (25%). Susceptibility was observed in the same percentage in both groups (62.5%). All ACB strains confirmed their intrinsic resistances. Non-ACB species showed lower resistances against antipseudomonal penicillins plus beta-lactamase inhibitors (P=0.1306), III generation cephalosporins (P=0.0547), and tetracyclines (P=0.0209) than ACB species. Carbapenem-resistance was observed for XDR A. baumannii (12.5%) and, in particular for MDR non-ACB complex members (25%). To our knowledge, A. lactucae represents the first description in two sick dogs in Italy. Furthermore, our results emphasize the role of non-ACB-complex species as important zoonotic pathogens, which could be reservoirs of clinically relevant resistance profiles. •baumannii has become clinically significant both in human and veterinary medicine.•Other species of the genus Acinetobacter also deserve justified attention.•Companion animals can harbor zoonotic non-A. calcoaceticus-baumannii complex strains.•Relevant MDR and XDR profiles were detected both for ACB and non-ACB complex members.•First description of MDR A. lactucae in two sick dogs in Italy.