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Yu, Yanlin; Dai, Meng; Huang, Liping; Chen, Weiping; Yu, Ellen; Mendoza, Arnulfo; Michael, Helen; Khanna, Chand; Bosenberg, Marcus; McMahon, Martin; Merlino, Glenn
iScience, 02/2023, Letnik: 26, Številka: 2Journal Article
PTEN encodes a tumor suppressor with lipid and protein phosphatase activities whose dysfunction has been implicated in melanomagenesis; less is known about how its phosphatases regulate melanoma metastasis. We demonstrate that PTEN expression negatively correlates with metastatic progression in human melanoma samples and a PTEN-deficient mouse melanoma model. Wildtype PTEN expression inhibited melanoma cell invasiveness and metastasis in a dose-dependent manner, behaviors that specifically required PTEN protein phosphatase activity. PTEN phosphatase activity regulated metastasis through Entpd5. Entpd5 knockdown reduced metastasis and IGF1R levels while promoting ER stress. In contrast, Entpd5 overexpression promoted metastasis and enhanced IGF1R levels while reducing ER stress. Moreover, Entpd5 expression was regulated by the ER stress sensor ATF6. Altogether, our data indicate that PTEN phosphatase activity inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6, thereby identifying novel candidate therapeutic targets for the treatment of PTEN mutant melanoma. Display omitted •PTEN expression negatively correlates with metastatic progression in melanoma•PTEN functions as a haploinsufficiency metastasis suppressor•PTEN phosphatase is required for blocking metastasis independent of lipid phosphatase•PTEN regulated metastasis by inhibiting Entpd5/IGF1R/ATF6 pathways Cell biology; Functional aspects of cell biology; Cancer
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