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Métairie, Marie; Benoit, Louise; Koual, Meriem; Bentivegna, Enrica; Wohrer, Henri; Bolze, Pierre-Adrien; Kerbage, Yohan; Raimond, Emilie; Akladios, Cherif; Carcopino, Xavier; Canlorbe, Geoffroy; Uzan, Jennifer; Lavoué, Vincent; Mimoun, Camille; Huchon, Cyrille; Koskas, Martin; Costaz, Hélène; Margueritte, François; Dabi, Yohann; Touboul, Cyril; Bendifallah, Sofiane; Ouldamer, Lobna; Delanoy, Nicolas; Nguyen-Xuan, Huyen-Thu; Bats, Anne-Sophie; Azaïs, Henri
Cancers, 01/2023, Letnik: 15, Številka: 3Journal Article
International Federation of Gynecology and Obstetrics (FIGO) staging classification for stage IV epithelial ovarian cancer (EOC) separates stages IVA (pleural effusion) and IVB (parenchymal and/or extra-abdominal lymph node metastases). We aimed to evaluate its prognostic impact and to compare survival according to the initial metastatic location. We conducted a multicenter study between 2000 and 2020, including patients with a FIGO stage IV EOC. Primary endpoint was overall survival (OS). The secondary endpoints were progression-free survival (PFS) and recurrence rates. We included 307 patients: 98 (32%) had FIGO stage IVA and 209 (68%) had FIGO stage IVB. The median OS and PFS of stage IVA patients were significantly lower than those of stage IVB patients (31 versus 45 months ( = 0.02) and 18 versus 25 months ( = 0.01), respectively). Recurrence rate was higher in stage IVA than IVB patients (65% versus 47% ( = 0.004)). Initial pleural involvement was a poor prognostic factor with a median OS of 35 months versus 49 months for patients without initial pleural involvement ( = 0.024). Patients with FIGO stage IVA had a worse prognosis than patients with FIGO stage IVB EOC. Pleural involvement appears to be relevant for predicting survival. We suggest a modification of the current FIGO staging classification.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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