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Martínez-Fleta, Pedro; Vicente-Rabaneda, Esther F; Triguero-Martínez, Ana; Roy-Vallejo, Emilia; Uriarte-Ecenarro, Miren; Gutiérrez-Rodríguez, Francisco; Quiroga-Colina, Patricia; Romero-Robles, Ana; Montes, Nuria; García-Castañeda, Noelia; Mejía-Abril, Gina P; García-Vadillo, Jesús A; Llorente-Cubas, Irene; Villagrasa, José R; Serra López-Matencio, José M; Ancochea, Julio; Urzainqui, Ana; Esparcia-Pinedo, Laura; Alfranca, Arantzazu; de la Fuente, Hortensia; García-Vicuña, Rosario; Sánchez-Madrid, Francisco; González-Álvaro, Isidoro; Castañeda, Santos
npj vaccines, 01/2024, Letnik: 9, Številka: 1Journal Article
B and T cell responses were evaluated in patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA) after 1 or 2 weeks of methotrexate (MTX) withdrawal following each COVID-19 vaccine dose and compared with those who maintained MTX. Adult RA and PsA patients treated with MTX were recruited and randomly assigned to 3 groups: MTX-maintenance (n = 72), MTX-withdrawal for 1 week (n = 71) or MTX-withdrawal for 2 weeks (n = 73). Specific antibodies to several SARS-CoV-2 antigens and interferon (IFN)-γ and interleukin (IL)-21 responses were assessed. MTX withdrawal in patients without previous COVID-19 was associated with higher levels of anti-RBD IgG and neutralising antibodies, especially in the 2-week withdrawal group and with higher IFN-γ secretion upon stimulation with pools of SARS-CoV-2 S peptides. No increment of RA/PsA relapses was detected across groups. Our data indicate that two-week MTX interruption following COVID-19 vaccination in patients with RA or PsA improves humoral and cellular immune responses.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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