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Montgomery, Jay A., MD; Abdallah, Wissam, MD; Yoneda, Zachary T., MD; Brittain, Evan, MD, MSCI; Aznaurov, Sam G; Parvez, Babar, MD; Adkins, Keith, RN, MSN; Whalen, S. Patrick, MD; Estrada, J.C., MD; Shen, Sharon, MD; Crossley, George H., MD; Kanagasundram, Arvindh, MD; Saavedra, Pablo, MD; Ellis, Christopher R., MD; Lawson, Mark, MD; Darbar, Dawood, MD; Shoemaker, M. Benjamin, MD, MSCI
Journal of arrhythmia, February 2016, Letnik: 32, Številka: 1Journal Article
Abstract Background Atrial fibrillation (AF) is associated with cardiac fibrosis, which can now be measured noninvasively using T1-mapping with cardiac magnetic resonance imaging (CMRI). This study aimed to assess the impact of AF on ventricular T1 at the time of CMRI. Methods Subjects with AF scheduled for AF ablation underwent CMRI with standard electrocardiography gating and breath-hold protocols on a 1.5 T scanner with post-contrast ventricular T1 recorded from 6 regions of interest at the mid-ventricle. Baseline demographic, clinical, and imaging characteristics were examined using univariate and multivariable linear regression modeling for an association with myocardial T1. Results One hundred fifty-seven patients were studied (32% women; median age, 61 years interquartile range {IQR}, 55–67, 50% persistent AF episodes>7 days or requiring electrical or pharmacologic cardioversion, 30% in AF at the time of the CMRI). The median global T1 was 404 ms (IQR, 381–428). AF at the time of CMRI was associated with a 4.4% shorter T1 ( p =0.000) com p ared to sinus rhythm when adjusted for age, sex, persistent AF, body mass index, congestive heart failure, and renal dysfunction (estimated glomerular filtration rate<60). A post-hoc multivariate model adjusted for heart rate suggested that heart rate elevation ( p =0.009) contributes to the reduction in T1 observed in patients with AF at the time of CMRI. No association between ventricular T1 and AF recurrence after ablation was demonstrated. Conclusion AF at the time of CMRI was associated with lower post-contrast ventricular T1 compared with sinus rhythm. This effect was at least partly due to elevated heart rate. T1 was not associated with the recurrence of AF after ablation.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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