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Elahi, Maryam Tavakol; Lee, Won Sook; Phan, Philippe
Canadian Journal of Surgery, 12/2022, Letnik: 65Journal Article
Background: Studies have demonstrated the correlation between fractional anisotropy (FA) and functional outcomes in patients with spinal cord injury (SCI), but there are a few studies correlating microstructural and macroscopic features in the healthy population. The primary objective of this study is to find whether there is any significant relation between macrostructural and microstructural characteristics of cervical spinal cord magnetic resonance (MR) images of the healthy population. Methods: We conducted a quantitative analysis on the spine generic public data set containing 260 healthy multi-subject MRI scans using the latest spinal cord toolbox. We experimented with T2w images to derive shape characteristics (cross-sectional area of the cord, space available for the cord) and diffusion-weighted imaging (DWI) to extract diffusion metrics (fractional anisotropy, mean diffusivity and radial diffusivity). After the preprocessing of extracted features, we proceeded with the Pearson correlation between each DWI metric and T2w macroscopic measurements; with more interest in finding the correlation between FA and space available for the cord / cross-sectional area (SAC/CSA). Results: There was moderate correlation between SAC/CSA and FA (r = 0.35), with moderate correlations, highly moderate, moderate, and slightly moderate to low correlations (r = 0.38, r = 0.33, r = 0.48, r = 0.40, r = 0.28) between SAC/CSA and FA in the male and female categories and the subgroups of images acquired with GE, Philips and Siemens MRI machines, respectively. In total, the correlations were computed for 12 various subcategories of images ranging from slightly moderate to low (r = 0.27) to highly moderate (r = 0.53) correlations, with a p value of 0.001 for all experiments. Conclusion: The relationships between anatomic and microstructural characteristics of the cervical spinal cord in the healthy population are presented. Results demonstrate a potential relationship between FA and SAC/CSA. These findings suggest that microstructural measurements might be used as a screening tool in addition to macroscopic features in populations suspected of SCI. The sensibility and threshold values of DWI metrics would need more clarification in the future. Further studies are required to evaluate the progression of the disease and its correlation with quantitative measurements.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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