The number of people living with and surviving cancer is growing on account of improved screening, early detection, and medical treatments (Mewes et al., 2012). Many cancer diagnoses emerge during prime employment years. There are mixed findings in the literature on the rates and benefits of cancer survivors returning to work. Similarly, the research on job satisfaction of cancer survivors is varied, with some identifying high levels of work satisfaction (Mehnert & Koch, 2013; Nachreiner et al., 2007) and others reporting lower levels of job satisfaction (Amir et al., 2007; Johnsson et al., 2011). Side effects of cancer treatment (Kamal et al., 2017; Mehnert, 2011; Todd et al., 2011) and lower vocational satisfaction of cancer survivors (Høyer et al., 2012; Johnsson et al., 2009) have been found to correlate with poorer work-related outcomes. Cognitive, physical, psychological, financial, and existential challenges can result from either from cancer or treatment. Given these changes in functioning and reevaluation of life priorities that many cancer survivors face, values pertaining to work can change. Such shifts in priorities are part of the psychosocial adjustment to cancer and can preserve and improve quality of life. Importantly, the way such values are lived out is through behaviors and actions that are in accordance with said values. These behavioral manifestations are virtues. Specifically, there are five virtues, as conceptualized by Kim, McMahon and colleagues (2016) in their Virtue-Based Psychosocial Adaptation Model: Committed Action, Emotional Transcendence, Practical Wisdom, Integrity, and Courage. The unique and personal enactment of each of these virtues culminates in virtuous living or flourishing. The purpose of this study was to examine the role of virtues and psychosocial adaptation in the satisfaction with labor market participation that cancer survivors experience. Simple mediation analyses demonstrated that committed action serves as a mediator for the other virtues. Subsequent parallel mediation analyses found adaptive and non-adaptive reactions to cancer mediate the relationship between virtues and satisfaction with labor market participation. Findings of this study extend the literature on virtues in the context of psychosocial adaptation for people with cancer. Implications for practices and future research are discussed.