E-viri
Recenzirano
Odprti dostop
-
Helgadottir, Anna, MD, PhD; Gretarsdottir, Solveig, PhD; Thorleifsson, Gudmar, PhD; Holm, Hilma, MD; Patel, Riyaz S., MD; Gudnason, Thorarinn, MD, PhD; Jones, Gregory T., PhD; van Rij, Andre M., MD; Eapen, Danny J., MD; Baas, Annette F., PhD; Tregouet, David-Alexandre, PhD; Morange, Pierre-Emmanuel, MD; Emmerich, Joseph, MD, PhD; Lindblad, Bengt, MD, PhD; Gottsäter, Anders, MD, PhD; Kiemeny, Lambertus A., PhD; Lindholt, Jes S., MD, PhD; Sakalihasan, Natzi, MD, PhD; Ferrell, Robert E., PhD; Carey, David J., PhD; Elmore, James R., MD; Tsao, Philip S., PhD; Grarup, Niels, MD, PhD; Jørgensen, Torben, MD, DMSci; Witte, Daniel R., MD, PhD; Hansen, Torben, MD, PhD; Pedersen, Oluf, MD, DMSci; Pola, Roberto, MD, PhD; Gaetani, Eleonora, MD; Magnadottir, Hulda B., MD; Wijmenga, Cisca, PhD; Tromp, Gerard, PhD; Ronkainen, Antti, MD, PhD; Ruigrok, Ynte M., MD; Blankensteijn, Jan D; Mueller, Thomas, MD; Wells, Philip S., MD; Corral, Javier, PhD; Soria, Jose Manuel, PhD; Souto, Juan Carlos, MD, PhD; Peden, John F., PhD; Jalilzadeh, Shapour, MD, PhD; Mayosi, Bongani M., DPhil; Keavney, Bernard, MD; Strawbridge, Rona J., PhD; Sabater-Lleal, Maria, PhD; Gertow, Karl, PhD; Baldassarre, Damiano, PhD; Nyyssönen, Kristiina, PhD; Rauramaa, Rainer, MD, PhD; Smit, Andries J., MD, PhD; Mannarino, Elmo, MD; Giral, Philippe, MD; Tremoli, Elena, PhD; de Faire, Ulf, MD, PhD; Humphries, Steve E., PhD; Hamsten, Anders, MD, PhD; Haraldsdottir, Vilhelmina, MD; Olafsson, Isleifur, MD, PhD; Magnusson, Magnus K., MD; Samani, Nilesh J., MD; Levey, Allan I., MD, PhD; Markus, Hugh S., MD; Kostulas, Konstantinos, MD, PhD; Dichgans, Martin, MD; Berger, Klaus, MD; Kuhlenbäumer, Gregor, MD; Ringelstein, E. Bernd, MD; Stoll, Monika, PhD; Seedorf, Udo, PhD; Rothwell, Peter M., MD, PhD; Powell, Janet T., MD; Kuivaniemi, Helena, MD, PhD; Onundarson, Pall T., MD; Valdimarsson, Einar, MD; Matthiasson, Stefan E., MD, PhD; Gudbjartsson, Daniel F., PhD; Thorgeirsson, Guðmundur, MD, PhD; Quyyumi, Arshed A., MD; Watkins, Hugh, MD, PhD; Farrall, Martin, MD; Thorsteinsdottir, Unnur, PhD; Stefansson, Kari, MD, PhD
Journal of the American College of Cardiology, 08/2012, Letnik: 60, Številka: 8Journal Article, Web Resource
Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene ( LPA ) on vascular diseases with different atherosclerotic and thrombotic components. Background It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. Methods The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST Trial of Org 10172 in Acute Stroke Treatment subtypes) (effective sample size ne = 9,396); peripheral arterial disease ( ne = 5,215); abdominal aortic aneurysm ( ne = 4,572); venous thromboembolism ( ne = 4,607); intracranial aneurysm ( ne = 1,328); CAD ( ne = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). Results LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio OR: 1.27; p = 6.7 × 10–4 ), peripheral artery disease (OR: 1.47; p = 2.9 × 10–14 ), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 × 10–5 ), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 × 10–12 ). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (–1.58 years/allele; p = 8.2 × 10–8 ) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). Conclusions LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.