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SUGIE, YUTAKA; HIRAI, HIDEO; INAGAKI, TAISUKE; ISHIGURO, MASARU; KIM, YOON-JEONG; KOJIMA, YASUHIRO; SAKAKIBARA, TATSUO; SAKEMI, SHINICHI; SUGIURA, AKEMI; SUZUKI, YUMIKO; BRENNAN, LORI; DUIGNAN, JOAN; HUANG, LIANG HSIUNG; SUTCLIFFE, JOYCE; KOJIMA, NAKAO
Journal of antibiotics, 2001, Letnik: 54, Številka: 11Journal Article
A new antibiotic, CJ-17, 665 (I) was isolated from the fermentation broth of Aspergillus ochraceus, CL41582. It inhibits growth of multi-drug resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25μg/ml, respectively. The structure contains a diketopiperazine and an indole N-oxide moiety that is unusual in natural products.
