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Ushijima, Tomokazu; Hanada, Kousuke; Gotoh, Eiji; Yamori, Wataru; Kodama, Yutaka; Tanaka, Hiroyuki; Kusano, Miyako; Fukushima, Atsushi; Tokizawa, Mutsutomo; Yamamoto, Yoshiharu Y.; Tada, Yasuomi; Suzuki, Yutaka; Matsushita, Tomonao
Cell, 11/2017, Letnik: 171, Številka: 6Journal Article
Alternative promoter usage is a proteome-expanding mechanism that allows multiple pre-mRNAs to be transcribed from a single gene. The impact of this mechanism on the proteome and whether it is positively exploited in normal organismal responses remain unclear. We found that the plant photoreceptor phytochrome induces genome-wide changes in alternative promoter selection in Arabidopsis thaliana. Through this mechanism, protein isoforms with different N termini are produced that display light-dependent differences in localization. For instance, shade-grown plants accumulate a cytoplasmic isoform of glycerate kinase (GLYK), an essential photorespiration enzyme that was previously thought to localize exclusively to the chloroplast. Cytoplasmic GLYK constitutes a photorespiratory bypass that alleviates fluctuating light-induced photoinhibition. Therefore, phytochrome controls alternative promoter selection to modulate protein localization in response to changing light conditions. This study suggests that alternative promoter usage represents another ubiquitous layer of gene expression regulation in eukaryotes that contributes to diversification of the proteome. Display omitted •Phytochrome induces genome-wide changes in alternative promoter selection•Phytochrome-mediated alternative promoter selection modulates protein localization•This mechanism produces a cytoplasmic isoform of glycerate kinase (cytGLYK)•cytGLYK accumulates in shade to alleviate fluctuating light-induced photoinhibition Light signaling through phytochrome receptors changes protein localization through alternative promoter selection, allowing plants to metabolically respond to changing light conditions.
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