The development process of on-board software applications can benefit from model-driven engineering techniques. Model validation and model transformations can be applied to drive the activities of specification, requirements definition, and system-level validation and verification according to the space software engineering standards ECSS-E-ST-40 and ECSS-Q-ST-80. This paper presents a model-driven approach to completing these activities by avoiding inconsistencies between the documents that support them and providing the ability to automatically generate the system-level validation tests that are run on the Ground Support Equipment and the matrices required to complete the software verification. A demonstrator of the approach has been built using as a proof of concept a subset of the functionality of the software of the control unit of the Energetic Particle Detector instrument on-board Solar Orbiter.