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Deng, Mario C.
Clinical transplantation, March 2017, 2017-03-00, 20170301, Letnik: 31, Številka: 3Journal Article
Over the last >20 years, we have co‐developed the rationale for the first diagnostic and prognostic leukocyte gene expression profiling (GEP) biomarker test in transplantation medicine that gained US‐FDA‐regulatory clearance and international evidence‐based medicine guideline acceptance to rule out moderate/severe acute cellular cardiac allograft rejection without invasive endomyocardial biopsies (EMB). Based on this test, a non‐invasive clinical algorithm was implemented since 2005. After clinical implementation, this GEP‐based monitoring in direct comparison with an EMB‐based strategy was non‐inferior with respect to detection of clinical rejection, defined as new onset allograft dysfunction with/without histology of ACR, re‐transplantation or death, and at the same time improved patient satisfaction. Subsequently, we demonstrated the test's capacity when used as serial monitoring tool to predict these clinical rejection events. In this Personal Viewpoint article, I will discuss the various decision‐making branching points that were made in the AlloMap biomarker test development to inform future genomic biomarker test development projects.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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