Display omitted •Crystallization of methane hydrate confined in a silica pore is described using MD.•Hydrate crystallizes occupying all the accessible volume, but presents many defects.•As in the case of ice, an interfacial liquid layer is observed between the hydrate and the confining silica walls. The growth of a methane hydrate seed within a silica slit pore of fixed width has been studied using All-Atom Molecular Dynamics (AA-MD). An AA force field has been used to describe the molecules of the solid silica substrate, with α-quartz crystalline structure. The crystallisation of hydrates in confined geometries is not well understood yet, and the objective of this work is to study the hydrate growth inside a silica pore using molecular simulation. Both NVT and NpT ensembles were used in the AA-MD simulations to analyse the hydrate growth from an initial seed. Results showed that the boundary conditions imposed by the nanometric slit pore yielded a hydrate with structural defects, filling the accessible space between the silica walls. The water molecules which were not incorporated to the initial seed hydrate formed a high density water layer trapped between the silica walls and the crystallised hydrate. These results provide an interesting insight into the hydrate crystallisation process in confined geometries, resembling those found in natural hydrate deposits.