•We develop a 3D material point method based on finite strain elastoplasticity.•The parameters possess a strong physical meaning, allowing a priori calibration.•We reproduce four full-scale, well documented, historical cascading events.•Complex processes naturally emerge from the simulations, granting accurate results. Alpine mass movements can generate process cascades involving different materials including rock, ice, snow, and water. Numerical modelling is an essential tool for the quantification of natural hazards. Yet, state-of-the-art operational models are based on parameter back-calculation and thus reach their limits when facing unprecedented or complex events. Here, we advance our predictive capabilities for mass movements and process cascades on the basis of a three-dimensional numerical model, coupling fundamental conservation laws to finite strain elastoplasticity. In this framework, model parameters have a true physical meaning and can be evaluated from material testing, thus conferring to the model a strong predictive nature. Through its hybrid Eulerian–Lagrangian character, our approach naturally reproduces fractures and collisions, erosion/deposition phenomena, and multi-phase interactions, which finally grant accurate simulations of complex dynamics. Four benchmark simulations demonstrate the physical detail of the model and its applicability to real-world full-scale events, including various materials and ranging through five orders of magnitude in volume. In the future, our model can support risk-management strategies through predictions of the impact of potentially catastrophic cascading mass movements at vulnerable sites.