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McGowan, Eileen; Lin, Qimou; Ma, Guocai; Yin, Haibin; Chen, Size; Lin, Yiguang
Biomedicine & pharmacotherapy, January 2020, 2020-Jan, 2020-01-00, 20200101, 2020-01-01, Letnik: 121Journal Article
•A review specifically summarising PD-1 disrupted CAR T cells as cancer therapeutics.•Antitumor activity of CAR T cells can be enhanced significantly by PD-1 disruption.•This new combination strategy could be the new hope for solid tumor treatment.•Increasing number of clinical trials on these CAR T cells have been commenced.•Future prospects & challenges of this new combination strategy are discussed. Unprecedented efficacy of chimeric antigen receptor (CAR) T cell therapy in the treatment of hematologic malignancies brings new hope for patients with many cancer types including solid tumors. However, the challenges for CAR-T cell therapy in eradicating solid tumors are immense. To overcome these seemingly intractable hurdles, more “powerful” CAR-T cells with enhanced antitumor efficacy are required. Emerging data support that the anti-tumor activity of CAR-T cells can be enhanced significantly without evident toxicity through simultaneous PD-1 disruption by genome editing. This review focuses on the current progress of PD-1 gene disrupted CAR-T cells in cancer therapy. Here we discuss key rationales for this new combination strategy and summarize the available pre-clinical studies. An update is provided on human clinical studies and available registered cancer clinical trials using CAR-T cells with PD-1 disruption. Future prospects and challenges are also discussed.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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