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Fujio, Yasushi; Matsuda, Takahisa; Oshima, Yuichi; Maeda, Makiko; Mohri, Tomomi; Ito, Takashi; Takatani, Tomoka; Hirata, Mayo; Nakaoka, Yoshikazu; Kimura, Ryusuke; Kishimoto, Tadamitsu; Azuma, Junichi
FEBS letters, August 27, 2004, Letnik: 573, Številka: 1Journal Article
Glycoprotein 130 (gp130), a common receptor of IL-6 family cytokines, plays critical roles in cardiac functions. Here, we demonstrate that the stimulation of gp130 with leukemia inhibitory factor (LIF) promoted cell adhesion in a cadherin-dependent manner in cultured cardiomyocytes. Wnt5a was upregulated by the stimulation of gp130 with IL-6 family cytokines, accompanied by N-cadherin protein upregulation. Wnt5a was not induced by LIF in cardiomyocytes expressing dominant-negative STAT3. Ablation of Wnt5a by antisense cDNA inhibited LIF-induced cell adhesion. Collectively, signals through gp130 upregulate Wnt5a through STAT3, promoting the N-cadherin-mediated cell adhesion.
