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Chan, Charles K.F.; Seo, Eun Young; Chen, James Y.; Lo, David; McArdle, Adrian; Sinha, Rahul; Tevlin, Ruth; Seita, Jun; Vincent-Tompkins, Justin; Wearda, Taylor; Lu, Wan-Jin; Senarath-Yapa, Kshemendra; Chung, Michael T.; Marecic, Owen; Tran, Misha; Yan, Kelley S.; Upton, Rosalynd; Walmsley, Graham G.; Lee, Andrew S.; Sahoo, Debashis; Kuo, Calvin J.; Weissman, Irving L.; Longaker, Michael T.
Cell, 01/2015, Letnik: 160, Številka: 1-2Journal Article
How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment. We demonstrate that mSSC niche factors can be potent inducers of osteogenesis, and several specific combinations of recombinant mSSC niche factors can activate mSSC genetic programs in situ, even in nonskeletal tissues, resulting in de novo formation of cartilage or bone and bone marrow stroma. Inducing mSSC formation with soluble factors and subsequently regulating the mSSC niche to specify its differentiation toward bone, cartilage, or stromal cells could represent a paradigm shift in the therapeutic regeneration of skeletal tissues. Display omitted •Bone, cartilage, and stroma are derived from clonal, lineage-restricted progenitors•We defined a postnatal skeletal stem cell (mSSC) and seven downstream progenitors•Skeletal progenitor fate can be directed from bone to cartilage and vice versa•Manipulation of mSSC niche signaling can induce de novo bone or cartilage formation Bone, cartilage, and stroma development in mice is mapped from a population of postnatal skeletal stem cells to their downstream progenitors of bone, cartilage, and stromal tissue.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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