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Nollmann, Friederike I.; Dauth, Christina; Mulley, Geraldine; Kegler, Carsten; Kaiser, Marcel; Waterfield, Nick R.; Bode, Helge B.
Chembiochem : a European journal of chemical biology, January 19, 2015, Letnik: 16, Številka: 2Journal Article
Discovery of new natural products by heterologous expression reaches its limits, especially when specific building blocks are missing in the heterologous host or the production medium. Here, we describe the insect‐specific production of the new GameXPeptides E–H (5–8) from Photorhabdus luminescens TTO1, which can be produced heterologously from expression of the GameXPeptide synthetase GxpS only upon supplementation of the production media with the missing building blocks, and thus must be regarded as the true natural products under natural conditions. The insect does the trick! Injection of P. luminescens into G. mellonella triggers the production of the unusual amino acid p‐aminophenylalanine (PAPA), its monomethylated derivate (MMPAPA), and novel GameXPeptides. Although the GameXPeptide‐producing GxpS enzyme is widespread amongst Photorhabdus and Xenorhabdus, only Photorhabdus bacteria also display the operon leading to the production of PAPA and MMPAPA.
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in: SICRIS
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