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Ferrucci, Pier Francesco; Gandini, Sara; Cocorocchio, Emilia; Pala, Laura; Baldini, Federica; Mosconi, Massimo; Antonini Cappellini, Gian Carlo; Albertazzi, Elena; Martinoli, Chiara
Oncotarget, 10/2017, Letnik: 8, Številka: 45Journal Article
As diverse therapeutic options are now available for advanced melanoma patients, predictive markers that may assist treatment decision are needed. A model based on baseline serum lactate dehydrogenase (LDH), peripheral blood relative lymphocyte counts (RLC) and eosinophil counts (REC) and pattern of distant metastasis, has been recently proposed for pembrolizumab-treated patients. Here, we applied this model to advanced melanoma patients receiving chemotherapy ( 116) or anti-CTLA-4 therapy ( 128). Visceral involvement, LDH and RLC were associated with prognosis regardless of treatment. Instead, when compared to chemotherapy-treated patients with REC < 1.5%, those with REC ≥ 1.5% had improved overall survival when receiving anti-CTLA-4 Hazard Ratio (HR) = 0.56 (0.4-0.93) but not chemotherapy HR = 1.13, (0.74-1.74), and the treatment-by-REC interaction was significant for both overall ( = 0.04) and progression free survival ( = 0.009). These results indicate baseline REC ≥ 1.5% as a candidate predictive biomarker for benefit from anti-CTLA-4. Further studies are needed to confirm these findings in patients receiving immune-modulating agents.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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