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Rosa Duque, Jaime S.; Wang, Xiwei; Leung, Daniel; Cheng, Samuel M. S.; Cohen, Carolyn A.; Mu, Xiaofeng; Hachim, Asmaa; Zhang, Yanmei; Chan, Sau Man; Chaothai, Sara; Kwan, Kelvin K. H.; Chan, Karl C. K.; Li, John K. C.; Luk, Leo L. H.; Tsang, Leo C. H.; Wong, Wilfred H. S.; Cheang, Cheuk Hei; Hung, Timothy K.; Lam, Jennifer H. Y.; Chua, Gilbert T.; Tso, Winnie W. Y.; Ip, Patrick; Mori, Masashi; Kavian, Niloufar; Leung, Wing Hang; Valkenburg, Sophie; Peiris, Malik; Tu, Wenwei; Lau, Yu Lung
Nature communications, 06/2022, Letnik: 13, Številka: 1Journal Article
Abstract We present an interim analysis of a registered clinical study (NCT04800133) to establish immunobridging with various antibody and cellular immunity markers and to compare the immunogenicity and reactogenicity of 2-dose BNT162b2 and CoronaVac in healthy adolescents as primary objectives. One-dose BNT162b2, recommended in some localities for risk reduction of myocarditis, is also assessed. Antibodies and T cell immune responses are non-inferior or similar in adolescents receiving 2 doses of BNT162b2 (BB, N = 116) and CoronaVac (CC, N = 123) versus adults after 2 doses of the same vaccine (BB, N = 147; CC, N = 141) but not in adolescents after 1-dose BNT162b2 (B, N = 116). CC induces SARS-CoV-2 N and N C-terminal domain seropositivity in a higher proportion of adolescents than adults. Adverse reactions are mostly mild for both vaccines and more frequent for BNT162b2. We find higher S, neutralising, avidity and Fc receptor-binding antibody responses in adolescents receiving BB than CC, and a similar induction of strong S-specific T cells by the 2 vaccines, in addition to N- and M-specific T cells induced by CoronaVac but not BNT162b2, possibly implying differential durability and cross-variant protection by BNT162b2 and CoronaVac, the 2 most used SARS-CoV-2 vaccines worldwide. Our results support the use of both vaccines in adolescents.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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