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Cho, Heewon; Kwon, Haw-Young; Sharma, Amit; Lee, Sun Hyeok; Liu, Xiao; Miyamoto, Naoki; Kim, Jong-Jin; Im, Sin-Hyeog; Kang, Nam-Young; Chang, Young-Tae
Nature communications, 10/2022, Letnik: 13, Številka: 1Journal Article
Abstract Macrophages play crucial roles in protecting our bodies from infection and cancers. As macrophages are multi-functional immune cells, they have diverse plastic subsets, such as M1 and M2, derived from naïve M0 cells. Subset-specific macrophage probes are essential for deciphering and monitoring the various activation of macrophages, but developing such probes has been challenging. Here we report a fluorescent probe, CDr17, which is selective for M1 macrophages over M2 or M0. The selective staining mechanism of CDr17 is explicated as Gating-Oriented Live-cell Distinction (GOLD) through overexpressed GLUT1 in M1 macrophages. Finally, we demonstrate the suitability of CDr17 to track M1 macrophages in vivo in a rheumatoid arthritis animal model.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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