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Elloumi‐Hannachi, I.; Yamato, M.; Okano, T.
Journal of internal medicine, January 2010, 2010, 2010-Jan, 2010-01-00, 20100101, Letnik: 267, Številka: 1Journal Article, Conference Proceeding
. Cell sheet technology (CST) is based on the use of thermoresponsive polymers, poly(N‐isopropylacrylamide) (PIPAAm). The surface of PIPAAms is formulated in such a way as to make its typical thickness <100 nm. In this review, we first focus on how the methods of PIPAAm‐grafted surface preparations and functionalization are important to be able to harvest a functional cell sheet, to be further transplanted. Then, we present aspects of tissue mimics and three‐dimensional reconstruction of a tissue in vitro. Finally, we give an overview of clinical applications and clinically relevant animal experimentations of the technology, such as cardiomyopathy, visual acuity, periodonty, oesophageal ulcerations and type 1 diabetes.
