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Vijayavenkataraman, Sanjairaj; Thaharah, Siti; Zhang, Shuo; Lu, Wen Feng; Fuh, Jerry Ying Hsi
Materials & design, 01/2019, Letnik: 162Journal Article
NGCs are considered as an alternative treatment method for treating peripheral nerve injuries in place of nerve autografts. Biomimicry, conductivity, and biodegradability are the properties expected of an ideal NGC. PCL/PAA NGCs with three different concentrations of PAA (2.5, 5 and 7.5%) were fabricated using EHD-jet 3D printing. The mechanical properties of the PCL/PAA NGCs mimic the native human nerve properties (ultimate tensile strength of 6.5 to 11.7 MPa) and the conductivity match that of the amphibian motor nerve fiber myelin sheath (10−6 S/cm). The in vitro degradation studies reveal that they are biodegradable and injury/site-specific biodegradability can be obtained by tuning the PCL/PAA concentration ratio. In addition, PAA being a polyanionic polymer has the potential to act as a cation-exchanger, mimicking the functions of the nerve cortical gel layer, thereby influencing the electrophysiological phenomena called nerve excitation and conduction. Neural differentiation studies with PC12 cells assessed by the Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and immunocytochemistry showed enhanced gene expression with the presence of PAA. Our results suggest that the EHD-jet 3D printed porous conductive PCL/PAA NGCs has the potential to be used in the treatment of peripheral nerve injuries. Display omitted •Ideal Nerve Guide Conduits with biomimicry and conductivity were fabricated using Electrohydrodynamic Jet 3D Printing•The mechanical properties and conductivity of the scaffolds mimic the native human nerve properties•Poly(acrylic acid) as cation-exchanger mimics nerve cortical gel layer functions, influencing nerve excitation & conduction•PC12 in vitro neural differentiation studies showed enhanced gene expression with the presence of Poly(acrylic acid)•Can potentially be used to treat peripheral nerve injuries & neurodegenerative conditions (Alzheimer’s and Parkinson’s)
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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