The present research work deals with the development of a time delayed chronotherapeutic formulation of felodipine (FD) aimed at rapid drug release after a desired lag time in the management of hypertension. The developed system comprises a drug core embedded within a swellable layer and coated with an insoluble, water permeable polymeric system. FD cyclodextrin complex was used as an active core while ethyl cellulose was used as an effective coating layer. Dissolution studies of the complex revealed that there was a 3-fold increase in dissolution of the complex compared to plain FD. This dissolution enhancement and rapid drug release resulted from FD amorphisation, as confirmed by XRD, DSC and SEM studies. FTIR and 1H NMR studies confirmed the complex formation between FD and cyclodextrin based on the observed hydrogen bond interactions. FD release was adequately adjusted by using a pH independent polymer, i.e., ethyl cellulose, along with dibutyl phthalate as plasticizer. Influence of formulation variables like polymer viscosity, plasticizer concentration, super disintegrant concentration in the swellable layer and percent coating weight gain was investigated to characterize the lag time. Upon permeation of water, the core tablet swelled, resulting in the rupture of the coating layer, followed by rapid drug release. The developed formulation of FD showed a lag time of 5-7 h, which is desirable for chronotherapeutic application. U radu je opisan razvoj kronoterapijskog pripravka felodipina (FD) za brzo osloba| anje ljekovite tvari nakon odre|enog vremenskog razdoblja u lije~enju hipertenzije. U tom pripravku FD kompleks sa ciklodekstrinom (ljekovita tvar) obavijen je slojem koji bubri i oblo`en etilcelulozom (netopljivi vodopropusni polimer). Osloba|anje iz FD kompleksa tri puta je pove}ano u odnosu na osloba|anje ~istog FD. Pove}anje koli~ine i brzine osloba|anja posljedica je amorfizacije felodipina, {to se pokazalo pomo}u XRD, DSC i SEM. FTIR i 1H NMR studije potvrdile su na temelju vodikovih veza da je stvoren kompleks izme|u FD i ciklodekstrina. Osloba|anje felodipina pode{eno je pomo}u pH neovisnog polimera, tj. pomo}u etilceluloze, te dibutil ftalata kao plastifikatora. Prou~avan je utjecaj formulacijskih varijabli kao {to su viskoznost polimera, koncentracija plastifikatora i superdezintegranta u sloju koji bubri te debljina oblo`nog sloja na vrijeme odgode po~etka osloba|anja. U vodenoj sredini oblo`ni sloj bubri i puca, nakon ~ega se lijek brzo osloba|a. U dobivenim pripravcima vrijeme odgode po~etka osloba|anja bilo je 5_7 h, {to je pogodno za kronoterapijsku primjenu.