Aim To describe the associations between positive and negative reactions of informal caregivers of people with dementia and health outcomes across eight European Countries. Background Caring for someone with dementia may have implications for the caregiver's own health and for the care recipient. These consequences could be associated with caregivers' reactions to the process of care. Design Association study based on cross‐sectional data. Methods Participants were people with dementia and their informal caregivers living at home or in long‐term care institutions. Data were collected between November 2010–April 2012 using the Caregiver Reaction Assessment (with dimensions of self‐esteem, lack of family support, financial problems, disrupted schedule and health problems) and associations were sought with informal caregiver burden, quality of life and psychological well‐being and with dementia sufferers' neuropsychiatric symptoms, comorbidity and dependency in activities of daily living using correlation coefficients. Results Data from 2014 participants were used. Variability across countries was noted, as well as differences between care at home and in long‐term care institutions. In general, self‐esteem and lack of family support correlated with caregiver burden and psychological well‐being. Associations were also found between disrupted schedule and caregiver burden, psychological well‐being and quality of life. Health problems were clearly associated with caregiver burden, psychological well‐being and quality of life. Conclusion Study results support links between the reactions of informal caregivers of people with dementia and health outcomes. These may have implications in terms of how services are addressed.