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Greene, Maxwell; Lai, Yongjie; Pajcini, Kostandin; Bailis, Will; Pear, Warren S; Lancaster, Eric
PloS one, 09/2016, Letnik: 11, Številka: 9Journal Article
Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.
