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Fumet, Jean-David; Richard, Corentin; Ledys, Fanny; Klopfenstein, Quentin; Joubert, Philippe; Routy, Bertrand; Truntzer, Caroline; Gagné, Andréanne; Hamel, Marc-André; Guimaraes, Camila Figueiredo; Coudert, Bruno; Arnould, Laurent; Favier, Laure; Lagrange, Aurélie; Ladoire, Sylvain; Saintigny, Pierre; Ortiz-Cuaran, Sandra; Perol, Maurice; Foucher, Pascal; Hofman, Paul; Ilie, Marius; Chevrier, Sandy; Boidot, Romain; Derangere, Valentin; Ghiringhelli, François
British journal of cancer, 10/2018, Letnik: 119, Številka: 8Journal Article
No study has evaluated the predictive and prognostic role of CD8 and PD-L1 coexpression in non-small-cell lung cancer (NSCLC). We analyzed RNA sequencing and/or immunohistochemistry staining in NSCLC patients from The Cancer Genome Atlas (n = 1016), and 34 metastatic NSCLC samples not treated by immunotherapy as prognostic cohorts. As predictive aspect of CD8 and PD-L1, we used 85 NSCLC patients treated with anti-PD-1. Two validation cohorts were used including 44 NSCLC patients treated with anti-PD-1 and an external cohort with different tumor types. In prognostic cohorts, high CD8A expression was associated with longer OS (p = 0.02), while high CD274 mRNA was associated with poor prognosis (p = 0.05). In predictive cohort, high CD8 expression and CD8A mRNA were associated with longer progression-free survival (PFS) (p = 0.0002). There was no significant association between PD-L1 expression and PFS while high CD274 mRNA was associated with longer PFS (p = 0.009). A combination of CD8A and CD274 was highly predictive of outcome. These results were confirmed in the validation cohorts. This two-genes signature demonstrated similar results compared to gold standard signatures. CD8 represents both a prognostic and predictive factor of outcomes, while PD-L1 share different prognostic and predictive roles.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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