E-viri
Recenzirano
Odprti dostop
-
GUDMUNDSSON, Julius; SULEM, Patrick; HELGADOTTIR, Hafdis Th; WEI LI; NAGY, Rebecca; RINGEL, Matthew D; KLOOS, Richard T; DE VISSER, Marieke C. H; PLANTINGA, Theo S; DEN HEIJER, Martin; AGUILLO, Esperanza; PANADERO, Angeles; GUDBJARTSSON, Daniel F; PRATS, Enrique; GARCIA-CASTANO, Almudena; DE JUAN, Ana; RIVERA, Fernando; BRAGI WALTERS, G; BJARNASON, Hjordis; TRYGGVADOTTIR, Laufey; EYJOLFSSON, Gudmundur I; BJORNSDOTTIR, Unnur S; HOLM, Hilma; JONASSON, Jon G; OLAFSSON, Isleifur; KRISTJANSSON, Kristleifur; KRISTVINSSON, Hoskuldur; MAGNUSSON, Olafur T; THORLEIFSSON, Gudmar; GULCHER, Jeffrey R; KONG, Augustine; KIEMENEY, Lambertus Alm; JONSSON, Thorvaldur; HJARTARSON, Hannes; MASSON, Gisli; MAYORDOMO, Jose I; NETEA-MAIER, Romana T; DE LA CHAPELLE, Albert; HRAFNKELSSON, Jon; THORSTEINSDOTTIR, Unnur; RAFNAR, Thorunn; STEFANSSON, Kari; HUILING HE; JONASDOTTIR, Aslaug; SIGURDSSON, Asgeir; STACEY, Simon N; JOHANNSDOTTIR, Hrefna
Nature genetics, 03/2012, Letnik: 44, Številka: 3Journal Article
To search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused our analysis on 22 SNPs with a P < 5 × 10(-8) in a genome-wide association study on levels of thyroid stimulating hormone (TSH) in 27,758 Icelanders. Of those, rs965513 has previously been shown to associate with thyroid cancer. The remaining 21 SNPs were genotyped in 561 Icelandic individuals with thyroid cancer (cases) and up to 40,013 controls. Variants suggestively associated with thyroid cancer (P < 0.05) were genotyped in an additional 595 non-Icelandic cases and 2,604 controls. After combining the results, three variants were shown to associate with thyroid cancer: rs966423 on 2q35 (OR = 1.34; P(combined) = 1.3 × 10(-9)), rs2439302 on 8p12 (OR = 1.36; P(combined) = 2.0 × 10(-9)) and rs116909374 on 14q13.3 (OR = 2.09; P(combined) = 4.6 × 10(-11)), a region previously reported to contain an uncorrelated variant conferring risk of thyroid cancer. A strong association (P = 9.1 × 10(-91)) was observed between rs2439302 on 8p12 and expression of NRG1, which encodes the signaling protein neuregulin 1, in blood.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.