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Gibbs, Daniel J; Tedds, Hannah M; Labandera, Anne-Marie; Bailey, Mark; White, Mark D; Hartman, Sjon; Sprigg, Colleen; Mogg, Sophie L; Osborne, Rory; Dambire, Charlene; Boeckx, Tinne; Paling, Zachary; Voesenek, Laurentius A C J; Flashman, Emily; Holdsworth, Michael J
Nature communications, 12/2018, Letnik: 9, Številka: 1Journal Article
The polycomb repressive complex 2 (PRC2) regulates epigenetic gene repression in eukaryotes. Mechanisms controlling its developmental specificity and signal-responsiveness are poorly understood. Here, we identify an oxygen-sensitive N-terminal (N-) degron in the plant PRC2 subunit VERNALIZATION(VRN) 2, a homolog of animal Su(z)12, that promotes its degradation via the N-end rule pathway. We provide evidence that this N-degron arose early during angiosperm evolution via gene duplication and N-terminal truncation, facilitating expansion of PRC2 function in flowering plants. We show that proteolysis via the N-end rule pathway prevents ectopic VRN2 accumulation, and that hypoxia and long-term cold exposure lead to increased VRN2 abundance, which we propose may be due to inhibition of VRN2 turnover via its N-degron. Furthermore, we identify an overlap in the transcriptional responses to hypoxia and prolonged cold, and show that VRN2 promotes tolerance to hypoxia. Our work reveals a mechanism for post-translational regulation of VRN2 stability that could potentially link environmental inputs to the epigenetic control of plant development.
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