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Alessandri, Cristiano; Ciccia, Francesco; Priori, Roberta; Astorri, Elisa; Guggino, Giuliana; Alessandro, Riccardo; Rizzo, Aroldo; Conti, Fabrizio; Minniti, Antonina; Barbati, Cristiana; Vomero, Marta; Pendolino, Monica; Finucci, Annacarla; Ortona, Elena; Colasanti, Tania; Pierdominici, Marina; Malorni, Walter; Triolo, Giovanni; Valesini, Guido
Arthritis research & therapy, 07/2017, Letnik: 19, Številka: 1Journal Article
Primary Sjögren's syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. In the current study, we aimed to investigate the possible pathogenic implication of autophagy in T lymphocytes in patients with pSS. Thirty consecutive pSS patients were recruited together with 20 patients affected by sicca syndrome and/or chronic sialoadenitis and 30 healthy controls. Disease activity and damage were evaluated according to SS disease activity index, EULAR SS disease activity index, and SS disease damage index. T lymphocytes were analyzed for the expression of autophagy-specific markers by biochemical, molecular, and histological assays in peripheral blood and labial gland biopsies. Serum interleukin (IL)-23 and IL-21 levels were quantified by enzyme-linked immunosorbent assay. Our study provides evidence for the first time that autophagy is upregulated in CD4 T lymphocyte salivary glands from pSS patients. Furthermore, a statistically significant correlation was detected between lymphocyte autophagy levels, disease activity, and damage indexes. We also found a positive correlation between autophagy enhancement and the increased salivary gland expression of IL-21 and IL-23, providing a further link between innate and adaptive immune responses in pSS. These findings suggest that CD4 T lymphocyte autophagy could play a key role in pSS pathogenesis. Additionally, our data highlight the potential exploitation of T cell autophagy as a biomarker of disease activity and provide new ground to verify the therapeutic implications of autophagy as an innovative drug target in pSS.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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