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Fernandes, Priyanka; Loubens, Manon; Marinach, Carine; Coppée, Romain; Baron, Ludivine; Grand, Morgane; Andre, Thanh-Phuc; Hamada, Soumia; Langlois, Anne-Claire; Briquet, Sylvie; Bun, Philippe; Silvie, Olivier
iScience, 02/2023, Letnik: 26, Številka: 2Journal Article
Plasmodium sporozoites are transmitted to a mammalian host during blood feeding by an infected mosquito and invade hepatocytes for initial replication of the parasite into thousands of erythrocyte-invasive merozoites. Here we report that the B9 protein, a member of the 6-cysteine domain protein family, is secreted from sporozoite micronemes and is required for productive invasion of hepatocytes. The N-terminus of B9 forms a beta-propeller domain structurally related to CyRPA, a cysteine-rich protein forming an essential invasion complex in Plasmodium falciparum merozoites. The beta-propeller domain of B9 is essential for sporozoite infectivity and interacts with the 6-cysteine proteins P36 and P52 in a heterologous expression system. Our results suggest that, despite using distinct sets of parasite and host entry factors, Plasmodium sporozoites and merozoites may share common structural modules to assemble protein complexes for invasion of host cells. Display omitted •Infectious Plasmodium sporozoites express the 6-cys protein B9•B9 is secreted from a specific subset of micronemes•B9 is required for sporozoite productive invasion of hepatocytes•B9 contains an essential CyRPA-like beta-propeller domain Microbiology; Microbiology parasite; Molecular microbiology
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