Abstract NUSES is a new space mission aiming to test innovative observational and technological approaches related to the study of low energy cosmic and gamma rays, high energy astrophysical neutrinos, Sun-Earth environment, Space weather and magnetosphere-ionosphere-lithosphere coupling (MILC). The satellite will host two payloads, named TERZINA and ZIRÉ. ZIRÉ will perform measurements of electrons, protons and light nuclei from few up to hundreds of MeV, also testing new tools for the detection of cosmic MeV photons, and monitoring of MILC signals. TERZINA will observe the Cherenkov light produced by EAS generated by cosmic ray primaries at very high energies and will monitor the light emissions from the Earth limb in the near UV and visible ranges at the ns time scale, thus testing the observational concept of detecting Earth skimming astrophysical high energy neutrinos. The scientific objectives and development status of the mission will be presented.