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Skidmore, Zachary L; Kunisaki, Jason; Lin, Yiing; Cotto, Kelsy C; Barnell, Erica K; Hundal, Jasreet; Krysiak, Kilannin; Magrini, Vincent; Trani, Lee; Walker, Jason R; Fulton, Robert; Brunt, Elizabeth M; Miller, Christopher A; Wilson, Richard K; Mardis, Elaine R; Griffith, Malachi; Chapman, William; Griffith, Obi L
Cancer genetics, 06/2022, Letnik: 264-265Journal Article
•Non-cirrhotic HCC genomically resembles cirrhotic HCC•Comprehensive genome- and transcriptome-wide profiling allows detection of novel structural variants, fusions, and undiagnosed viral infections•NR1H4 fusions may represent a novel mechanism for tumorigenesis in HCC•Non-cirrhotic HCC is characterized by genotoxic mutational signatures and dysregulated liver metabolism•Clinical history and comprehensive omic profiling incompletely explain underlying etiologies for non-cirrhotic HCC highlighting the need for further research
