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Altschuler, R.A; Dolan, D.F; Halsey, K; Kanicki, A; Deng, N; Martin, C; Eberle, J; Kohrman, D.C; Miller, R.A; Schacht, J
Neuroscience, 04/2015, Letnik: 292Journal Article
Highlights • Loss of inner hair cell–auditory nerve connections precedes hair cell loss in most of the cochlea. • Loss of gap detection precedes hair cell loss in the basal two-thirds of the cochlea. • Loss of connections may contribute to but does not account for all of the age-related reduced gap detection. • Decrease in Ntf3 expression occurs at the same time as loss of inner hair cell–auditory nerve connections. • Hair cell loss and ABR thresholds increase significantly from 22–24 months to 27–29 months of age.
