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Yoon, Sung-Han, MD; Bleiziffer, Sabine, MD; De Backer, Ole, MD; Delgado, Victoria, MD; Arai, Takahide, MD; Ziegelmueller, Johannes, MD; Barbanti, Marco, MD; Sharma, Rahul, MD; Perlman, Gidon Y., MD; Khalique, Omar K., MD; Holy, Erik W., MD; Saraf, Smriti, MD; Deuschl, Florian, MD; Fujita, Buntaro, MD; Ruile, Philipp, MD; Neumann, Franz-Josef, MD; Pache, Gregor, MD; Takahashi, Masao, MD; Kaneko, Hidehiro, MD; Schmidt, Tobias, MD; Ohno, Yohei, MD; Schofer, Niklas, MD; Kong, William K.F., MD; Tay, Edgar, MD; Sugiyama, Daisuke, MD; Kawamori, Hiroyuki, MD; Maeno, Yoshio, MD; Abramowitz, Yigal, MD; Chakravarty, Tarun, MD; Nakamura, Mamoo, MD; Kuwata, Shingo, MD; Yong, Gerald, MD; Kao, Hsien-Li, MD; Lee, Michael, MD; Kim, Hyo-Soo, MD; Modine, Thomas, MD; Wong, S. Chiu, MD; Bedgoni, Francesco, MD; Testa, Luca, MD; Teiger, Emmanuel, MD; Butter, Christian, MD; Ensminger, Stephan M., MD; Schaefer, Ulrich, MD; Dvir, Danny, MD; Blanke, Philipp, MD; Leipsic, Jonathon, MD; Nietlispach, Fabian, MD; Abdel-Wahab, Mohamed, MD; Chevalier, Bernard, MD; Tamburino, Corrado, MD; Hildick-Smith, David, MD; Whisenant, Brian K., MD; Park, Seung-Jung, MD; Colombo, Antonio, MD; Latib, Azeem, MD; Kodali, Susheel K., MD; Bax, Jeroen J., MD; Søndergaard, Lars, MD; Webb, John G., MD; Lefèvre, Thierry, MD; Leon, Martin B., MD; Makkar, Raj, MD
Journal of the American College of Cardiology, 2017Journal Article
Abstract Background Transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis (AS) is being increasingly performed. Objectives From the Bicuspid AS TAVR multicenter registry, the procedural and clinical outcomes in patients with bicuspid versus tricuspid AS were compared. Methods Outcomes of 561 patients with bicuspid AS and 4,546 patients with tricuspid AS were compared after propensity-score matching assembling 546 pairs of patients with similar baseline characteristics. Procedural and clinical outcomes were recorded according to VARC-2 criteria. Results Compared to patients with tricuspid AS, patients with bicuspid AS had more frequent conversion to surgery (2.0% vs. 0.2%; p=0.006) and significantly lower device success rate (85.3% vs. 91.4%; p=0.002). Early generation devices (Sapien XT/CoreValve) were implanted in 320 patients with bicuspid and 321 patients with tricuspid AS whereas new generation devices (Sapien 3/Lotus/Evolut R) were implanted in 226 and 225 patients with bicuspid and tricuspid AS, respectively. Within the group receiving early generation devices, bicuspid AS had more frequent aortic root injury (4.5% vs. 0.0%; p=0.015) when receiving the Sapien XT, and moderate-to-severe paravalvular leak (19.4% vs. 10.5%; p=0.02) when receiving the CoreValve. Among patients with new generation devices, however, procedural results were comparable across different prostheses. The cumulative all-cause mortality rates at 2-year were comparable between bicuspid and tricuspid AS (17.2% vs. 19.4%; p=0.28). Conclusions Compared to tricuspid AS, TAVR in bicuspid AS was associated with similar prognosis although lower device success rate. Procedural differences were observed in patients treated with the early generation devices whereas no differences were observed with the new generation devices.
