This study aimed to identify entrepreneurship strategies and measure their impact on the success of the University of Science and Technology Hospital, Sana’a. It also aimed to identify the degree to which entrepreneurship strategies are practiced. To achieve the objectives of the study, the analytical descriptive method was used, and the questionnaire was developed for collecting primary data from a stratified random sample of (258) employees of which (240) questionnares were valid for analysis. Based on the data analysis and the hypotheses testing, the study showed that there was a positive impact of entrepreneurship strategies on achieving the success of the University of Science and Technology Hospital, the results also revealed that the level of distinctiveness in the hospital was very high, and the level of innovation, risk, and initiative practicing was high, while creativity was of a medium degree. The level of efficiency and effectiveness of the hospital was also high. The study recommends that the hospital management should continue to adopt leadership strategies in its strategic plans.