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Covalently conjugated NOD2/TLR7 agonists are potent and versatile immune potentiators [Elektronski vir]Guzelj, Samo ...The success of vaccination with subunit vaccines often relies on the careful choice of adjuvants. There is great interest in developing new adjuvants that can elicit a cellular immune response. Here, ... we address this challenge by taking advantage of the synergistic cross-talk between two pattern recognition receptors: nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) and Toll-like receptor 7 (TLR7). We designed two conjugated NOD2/TLR7 agonists, which showed potent immunostimulatory activities in human primary peripheral blood mononuclear cells and murine bone-marrow-derived dendritic cells. One of these, 4, also generated a strong antigen-specific immune response in vivo, with a Th1-polarized profile. Importantly, our study shows that novel NOD2/TLR7 agonists elicit sophisticated and fine-tuned immune responses that are inaccessible to individual NOD2 and TLR7 agonists.Source: Journal of medicinal chemistry [Elektronski vir]. - ISSN 1520-4804 (Vol. 65, no. 22, 2022, str. 15085–15101)Type of material - e-article ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 128189187
Author
Guzelj, Samo |
Weiss, Matjaž |
Slütter, Bram |
Frkanec, Ruža |
Jakopin, Žiga
Topics
Cepiva |
Imunski odziv |
immunostimulatory activity |
vaccines |
immune responses |
pattern recognition receptors |
synthesis of NOD2 agonist |
Toll-like receptor 7 |
imunostimulatorna aktivnost |
imunski odziv |
receptorji za prepoznavanje vzorcev |
sinteza agonista NOD2 |
Tollu podoben receptor 7
Author | Guzelj, Samo ... |
Title | Covalently conjugated NOD2/TLR7 agonists are potent and versatile immune potentiators [Elektronski vir] |
Publication date | |
COBISS.SI-ID | 128189187 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin | P1-0208-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Napredna imunološka zdravila in celični pristopi v farmaciji | P1-0420-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Razvoj agonistov receptorja NOD2 ter dualnih NOD2/TLR7 agonističnih konjugatov kot novih adjuvansov za cepiva | J3-9256-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c00808# |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=143233 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Guzelj, Samo | 52379 |
Weiss, Matjaž | 50503 |
Slütter, Bram | |
Frkanec, Ruža | |
Jakopin, Žiga | 26496 |
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