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Basophil response and the induction of a tolerance in venom immunotherapy : a long-term sting challenge studyEržen, Renato ...Background: There is no in vitro test to predict the induction of long-term tolerance in patients treated with venom immunotherapy (VIT). The aim of this study was to investigate whether ... immunotherapy-induced changes in basophil responsiveness reflect a state of protection and the induction of a tolerance.Methods: Twenty-three patients with allergic reaction after Hymenoptera sting (11 wasp and 12 honeybee) were treated with VIT. In all patients, a CD63 basophil activation test was performed before the beginning of immunotherapy, after 1 year and after completing 4-6.5 years of immunotherapy (approximately 1 year after stopping). The tolerance was then evaluated by a sting challenge test. The basophil activation test was repeated3-6 months after the challenge. Results: Twenty-two subjects showed a negative sting challenge, and one subject, a positive sting challenge. Allergen-specific basophil response remained unchanged after 1 year of immunotherapy. However, after immunotherapy, a significant and approximately fourfold decrease was demonstrated in all tolerant subjects mainly in response to submaximal 0.1 mug/ml allergen concentration. This depression wassustained and did not change with the sting challenge test. In a nontolerant patient with a positive sting challenge, basophil response did notchange. Conclusions: Our results suggest that the depression of allergen-specific basophil response seems to be associated with the induction of a tolerance after completing a course of VIT.Vir: Allergy. - ISSN 0105-4538 (Vol. 67, iss. 6, 2012, str. 822-830)Vrsta gradiva - članek, sestavni delLeto - 2012Jezik - angleškiCOBISS.SI-ID - 29842393
Avtor
Eržen, Renato |
Košnik, Mitja |
Šilar, Mira |
Korošec, Peter, 1970-
Teme
Bee Venoms |
Wasp Venoms |
Insect Bites And Stings |
Hypersensitivity |
Basophil Degranulation Test |
Immune Tolerance |
Desensitization, Immunologic |
Ige |
Igg |
Hymenoptera |
Basophils |
Prospective Studies |
Čebelji strupi |
Osji strupi |
Preobčutljivost |
Insekti, ugrizi in piki |
Bazofilna degranulacija, testi |
Prospektivne študije |
Bazofilci |
Desenzibilizacija imunska |
Hymenoptera |
Imunska toleranca |
IgG |
IgE
Vnos na polico
Trajna povezava
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Eržen, Renato | 25171 |
Košnik, Mitja | 10921 |
Šilar, Mira | 25331 |
Korošec, Peter, 1970- | 22807 |
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