VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Basophil response and the induction of a tolerance in venom immunotherapy : a long-term sting challenge study
    Eržen, Renato ...
    Background: There is no in vitro test to predict the induction of long-term tolerance in patients treated with venom immunotherapy (VIT). The aim of this study was to investigate whether ... immunotherapy-induced changes in basophil responsiveness reflect a state of protection and the induction of a tolerance.Methods: Twenty-three patients with allergic reaction after Hymenoptera sting (11 wasp and 12 honeybee) were treated with VIT. In all patients, a CD63 basophil activation test was performed before the beginning of immunotherapy, after 1 year and after completing 4-6.5 years of immunotherapy (approximately 1 year after stopping). The tolerance was then evaluated by a sting challenge test. The basophil activation test was repeated3-6 months after the challenge. Results: Twenty-two subjects showed a negative sting challenge, and one subject, a positive sting challenge. Allergen-specific basophil response remained unchanged after 1 year of immunotherapy. However, after immunotherapy, a significant and approximately fourfold decrease was demonstrated in all tolerant subjects mainly in response to submaximal 0.1 mug/ml allergen concentration. This depression wassustained and did not change with the sting challenge test. In a nontolerant patient with a positive sting challenge, basophil response did notchange. Conclusions: Our results suggest that the depression of allergen-specific basophil response seems to be associated with the induction of a tolerance after completing a course of VIT.
    Vir: Allergy. - ISSN 0105-4538 (Vol. 67, iss. 6, 2012, str. 822-830)
    Vrsta gradiva - članek, sestavni del
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 29842393
    DOI

vir: Allergy. - ISSN 0105-4538 (Vol. 67, iss. 6, 2012, str. 822-830)
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